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BRCA1.King’s group now wants to routinely test certain women for other cancer-linked genes Other researchers however argued that it is premature to test for these other genes which are less well understood Doctors often offer women with breast cancer in their family testing for mutations in BRCA1 and a related gene BRCA2 If the tests are positive some women may take preventive measures Earlier this year for example actress Angelina Jolie drew widespread attention for her decision to have a double mastectomy because she inherited a version of BRCA1 that carries an 87% risk of developing breast cancer Many women with breast cancer in their family don’t test positive for BRCA mutations however At the meeting Tomas Walsh of the University of Washington Seattle reported on a test he and King developed called BROCA that sequences not only the BRCA genes but also about 38 other cancer risk genes They ran the BROCA test on nearly 2300 women from 743 families with breast cancer In 77 families they did not find BRCA mutations but did find changes in other genes they say are definitely linked to breast cancer such as TP53 and CHEK2 Another 41 families carried mutations in a larger set of genes whose role in cancer is “emerging” Walsh said King and Walsh aren’t just using their BROCA test in research however—their university is also offering it as a clinical test to patients And physicians elsewhere can order the commercial test That did not sit well with other researchers in today’s session?

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